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2 article(s) from Beuck, Christine

NMR Spectroscopy of supramolecular chemistry on protein surfaces

Peter Bayer,
Anja Matena and
Christine Beuck

Beilstein J. Org. Chem. 2020, 16, 2505–2522, doi:10.3762/bjoc.16.203

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Graphical Abstract

Figure 1: Ligands targeting charged areas on protein surfaces discussed in this review. The protein shown as ...

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Figure 2: ¹H NMR titration of lysine with tweezers. All signals show chemical shift perturbations and differe...

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Figure 3: ¹H,¹⁵N-HSQC Titration of full-length hPin1 with supramolecular tweezers (original data). (a) Spectr...

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Figure 4: Relative signal intensities can be used to identify ligand binding sites (schematic representation ...

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Figure 5: Schematic ¹H,¹⁵N-HSQC spectrum of tauF4 (chemical shifts from BMRB # 17945, [109]) with and without spec...

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Figure 6: H2(C)N spectra specific for arginine (a) and lysine (b) residues of the hPin1-WW domain at differen...

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Review

Published 09 Oct 2020

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Reversibly locked thionucleobase pairs in DNA to study base flipping enzymes

Christine Beuck and
Elmar Weinhold

Beilstein J. Org. Chem. 2014, 10, 2293–2306, doi:10.3762/bjoc.10.239

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Figure 1: Covalent cross-linking of a I^6S/U^4S or G^6S/U^4S base pair within duplex ODN 1∙2 (a) by bis-alkylatio...

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Figure 2: Characterization of HPLC-purified cross-linked duplex 1^I6S-Et-S4U2 (a) by denaturing anion exchange...

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Figure 3: Characterization of HPLC-purified cross-linked duplex 1^G6S-Et-S4U2 (a) by denaturing anion exchange...

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Figure 4: Opening and traceless linker removal of the cross-linked duplexes 1^I6S-Et-S4U2 and 1^G6S-Et-S4U2 by ...

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Figure 5: UV time course of opening of the cross-link in duplex 1^I6S-Et-S4U2 with the thiol nucleophiles DTT ...

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Figure 6: Competition binding of M.TaqI to DNA with unlocked and locked target base pairs. Increasing amounts...

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Supp Info

Full Research Paper

Published 01 Oct 2014

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